Malawi Source: World Health Organization Please refer to the attached file. Executive Summary The year 2025 was defined by a dual imperative for Malawi’s health sector: sustaining essential services amid persistent challenges while advancing the structural reforms needed for long term resilience. Against a backdrop of fiscal tightening, climate-related disruptions, and recurrent disease outbreaks, the World Health Organization worked hand-in-hand with the Ministry of Health and Sanitation to protect population health and accelerate progress towards implementation of the Health Sector Strategic Plan III (2023–2030). Malawi developed its first fully costed five-year National Action Plan for Health Security, a multisectoral roadmap grounded in the International Health Regulations that shifted the country from reactive, fragmented investments toward a cohesive, risk-informed approach to preparedness. Malawi became the 62nd country globally to undertake the Quadripartite National Bridging Workshop and responded effectively to seven concurrent public health emergencies reaching over 10 million people including Cyclones Jude and Chido, cholera containment within six months, and the first-ever Mpox Treatment Centre established at Kamuzu Central Hospital within 48 hours of the first confirmed case. Mpox testing achieved 99.6% coverage the highest in the WHO African Region. Malawi became the first country in the African region and second globally to implement a comprehensive Nationwide AMR Burden Survey enrolling 10,226 patients, while reducing blood culture turnaround time from 14 to 4 days and securing endorsement of the Second National AMR Action Plan (2025–2030). WHO supported strengthened surveillance, expanded laboratory and genomic capacities, timely deployment of vaccines and supplies, and enhanced coordination at national and district levels, enabling rapid detection and containment that minimized impact on vulnerable communities. These experiences reaffirmed that an